Leading archaeologists and historians provide new studies of slavery, slave resistance and the economic, environmental and political consequences of slave trading in Africa, from the first millennium AD through to the nineteenth century.

MacDonald develops an evolutionary perspective on Judaism. Judaism is conceptualized as a group evolutionary strategy characterized by a high degree of endogamy and resistance to genetic and cultural assimilation. Data are provided to support the author's theory that Judaism is characterized by a high level of within-group altruism and competition with outgroups. Finally, MacDonald argues that Judaism has been characterized by eugenic practices aimed at high intelligence and high investment parenting. After outlining a theory of evolutionary group strategies, (...) MacDonald discusses the evidence from modern studies showing population genetic differences between Jews and Gentiles. He then shows that Jewish religious writing points to a pronounced tendency toward idealizing endogamy and condemning exogamy, and he points to the ways religious ideology and practice have facilitated the genetic and cultural separation of Jews and Gentiles. He then reviews evidence for resource and reproductive competition and the importance of kin-based cooperation and altruism as well as assortative mating for intelligence and resource aquisition ability among Jews. This study is a highly original attempt to develop an evolutionary understanding of one of the world's great religions. As such, it will be of concern to scholars and researchers in the fields of sociobiology and religion as well as the general reading public. (shrink)

The purpose of this article is to develop a model of life history theory that incorporates environmental influences, contextual influences, and heritable variation. I argue that physically or psychologically stressful environments delay maturation and the onset of reproductive competence. The social context is also important, and here I concentrate on the opportunity for upward social mobility as a contextual influence that results in delaying reproduction and lowering fertility in the interest of increasing investment in children. I also review evidence that (...) variation in life history strategies is influenced by genetic variation as well. Finally, I show that cultural shifts in the social control of sexual behavior have had differential effects on individuals predisposed to high- versus low-investment reproductive strategies. (shrink)

The role of Jewish activism in the transformative changes that have occurred in the West in recent decades continues to be controversial. Here I respond to several issues putatively related to Jewish influence, particularly the “default hypothesis” that Jewish IQ and urban residency explain Jewish influence and the role of the Jewish community in enacting the 1965 immigration law in the United States; other issues include Jewish ethnocentrism and intermarriage and whether diaspora Jews are hypocritical in their attitudes on immigration (...) to Israel versus the United States. The post-World War II era saw the emergence of a new, substantially Jewish elite in America that exerted influence on a wide range of issues that formed a virtual consensus among Jewish activists and the organized Jewish community, including immigration, civil rights, and the secularization of American culture. Jewish activism in the pro-immigration movement involved: intellectual movements denying the importance of race in human affairs; establishing, staffing, and funding anti-restrictionist organizations; recruiting prominent non-Jews to anti-restrictionist organizations; rejecting the ethnic status quo as a goal because of fear of a relatively homogeneous white majority; leadership in Congress and the executive branch. (shrink)

Domain-general mechanisms are evolutionarily ancient, resulting from the evolution of affective cues signaling the attainment of evolutionary goals. Explicit processing is a particularly important set of domain-general mechanisms for constructing human groups – enabling ideologies specifying future goal states and rationalizing group aims, enabling knowledge of others' reputations essential to cooperation, understanding the rights and obligations of group membership, monitoring group members, and providing appropriate punishments to those who deviate from group aims.

Stanovich & West's assumption of discrete System 1 and System 2 mechanisms is questionable. System 2 can be understood as emerging from individuals who score high on several normally distributed cognitive mechanisms supporting System 1. Cognitions ascribed to System 1 and System 2 appear to be directed toward the same evolutionary significant goals, and thus are likely to have emerged from the same selection pressures.

Campbell's target article significantly advances the field but fails to give adequate weight to individual differences. Moreover, there is no convincing rationale why males gain by making females less aggressive than they would otherwise be. It is also as likely that patriarchal ideology serves women's interests by canalizing genetic influences on individual differences within a more adaptively circumscribed range as it is to counter their interests by preventing them from challenging male hegemony.

This commentary argues that age changes in heritability are incompatible with Charney's theory. The new genetics must be tempered by the findings that many epigenetic phenomena are random and are linked to pathology, thus making them peripheral to the design of complex adaptations. Behavior-genetic findings are compatible with strong maternal effects; G E interactions are unlikely to be an important aspect of normal development.

The Ceci et al. article is consistent with tenure being a necessary condition for controversial research. In the absence of tenure, as in the United Kingdom, professors have been fired and suspended for politically controversial issues. There are a variety of reasons why tenure does not ensure that professors will engage in controversial research, including career interests and the desire to be liked. (Published Online February 8 2007).

This commentary focuses on the omission of genetic and environmental variation in several competing evolved motive dispositions that not only react to different environmental contexts but also result in people structuring contexts to obtain psychological rewards. Cross-cultural research is poor evidence for alternate strategies because natural selection may operate to produce geographical variation in dispositional tendencies. Finally, I defend a traditional concept of plasticity in opposition to the alternate strategies concept of flexibility.

The evolutionary theory of sex implies a theoretically principled account of the causal mechanisms underlying personality systems in which males pursue a relatively high-risk strategy compared to females and are thus higher on traits linked to sensation seeking and social dominance. Females are expected to be lower on these traits but higher on traits related to nurturance and attraction to long-term relationships. The data confirm this pattern of sex differences. It is thus likely that these traits have been a focus (...) of natural selection rather than the traits of gregarious/aloof and arrogant/unassuming hypothesized by Depue & Collins. (shrink)

Averageness is purportedly the result of stabilizing selection maintaining the population mean, whereas facial paedomorphosis is a product of directional selection driving the population mean towards an increasingly juvenile appearance. If selection is predominantly stabilizing, intermediate phenotypes reflect high genetic quality and mathematically average faces should be found attractive. If, on the other hand, directional selection is strong enough, extreme phenotypes reflect high genetic quality and juvenilized faces will be found attractive. To compare the effects of stabilizing and directional selection (...) on facial paedomorphosis (juvenilization), graphic morphing and editing techniques were used to alter the appearance of composite faces to make them appear more or less juvenile. Both facial models and judges of attractiveness were from the CSU-Long Beach campus. Although effect sizes for both preferences were large, the effect for averageness was nearly twice that found for juvenilization, an indication that stabilizing selection influences preferences for facial paedomorphosis more so than directional selection in contemporary humans. (shrink)

Niche construction refers to the activities of organisms that bring about changes in their environments, many of which are evolutionarily and ecologically consequential. Advocates of niche construction theory (NCT) believe that standard evolutionary theory fails to recognize the full importance of niche construction, and consequently propose a novel view of evolution, in which niche construction and its legacy over time (ecological inheritance) are described as evolutionary processes, equivalent in importance to natural selection. Here, we subject NCT to critical evaluation, in (...) the form of a collaboration between one prominent advocate of NCT, and a team of skeptics. We discuss whether niche construction is an evolutionary process, whether NCT obscures or clarifies how natural selection leads to organismal adaptation, and whether niche construction and natural selection are of equivalent explanatory importance. We also consider whether the literature that promotes NCT overstates the significance of niche construction, whether it is internally coherent, and whether it accurately portrays standard evolutionary theory. Our disagreements reflect a wider dispute within evolutionary theory over whether the neo-Darwinian synthesis is in need of reformulation, as well as different usages of some key terms (e.g., evolutionary process). (shrink)

A robust result in research on the production of grammatical agreement is that speakers are more likely to produce an erroneous verb with phrases such as the key to the cabinets, with a singular noun followed by a plural one, than with phrases such as the keys to the cabinet, where a plural noun is followed by a singular. These asymmetries are thought to reflect core language production processes. Previous accounts have attributed error patterns to a syntactic number feature present (...) on plurals but not singulars. An alternative approach is presented in which a process similar to structural priming contributes to the error asymmetry via speakers' past experiences with related agreement constructions. A corpus analysis and two agreement production studies test this account. The results suggest that agreement production is shaped by statistical learning from past language experience. Implications for accounts of agreement are discussed. (shrink)

The two target articles in this issue draw an important connection between disability bioethics and geriatric bioethics. Dominic JC Wilkinson makes a pragmatic case for using frailty as a fa...

BackgroundThe proper and ethical inclusion of PWLHIV and their young children in research is paramount to ensure valid evidence is generated to optimize treatment and care. Little empirical data exists to inform ethical considerations deemed most critical to these populations. Our study aimed to systematically review the empiric literature regarding ethical considerations for research participation of PWLHIV and their young children.MethodsWe conducted this systematic review in partnership with a medical librarian. A search strategy was designed and performed within the following (...) electronic databases: Ovid MEDLINE, Embase and CINAHL. We screened titles and abstracts using the following inclusion criteria: (1) a study population of PWLHIV or children under 5 years of age; and (2) collection of qualitative or quantitative data regarding ethics of research participation. Excluded were reviews, commentaries, policy statements, clinical care-related ethics concerns, abstracts, case studies, or studies unrelated to HIV research. Studies were appraised for quality, data were extracted, and studies were qualitatively analyzed using a principle-based ethical framework within the Belmont Report.ResultsOf the 7470 titles identified, 538 full-text articles were reviewed for eligibility and only three articles met full criteria for inclusion within this review. While we allowed for inclusion of studies involving young children born to mothers with HIV, only articles focused on PWLHIV were identified. Within the results of these studies, four themes emerged: (1) adequacy of informed consent; (2) consideration of paternal involvement; (3) balancing risks; and (4) access to research and treatment. A strength of this review is that it included perspectives of international research investigators, community leaders, and male partners. However, only two studies collected empiric data from PWLHIV regarding their experiences participating in researchConclusionResearchers and funding agencies should be aware of these considerations and appreciate the value of and critical need for formative research to ensure clinical trials involving PWLHIV promote ethical, well-informed research participation and, ultimately, improve care outcomes. More research is needed to create a comprehensive ethical framework for researchers when conducting studies with PWLHIV. (shrink)

Here we describe how more important findings were obtained in a delirium study by using an informal assessment of mental capacity, and, in those who lacked capacity, obtaining consent later when or if capacity returned or a proxy was found. From a total of 233 patients 23 patients lacked capacity as judged by our informal capacity judgment and 210 did not. Of those who lacked capacity, 13 agreed to enter in the study. Six of them regained capacity later. When these (...) 13 participants were excluded from analysis, significant findings were no longer evident. These results show that by the inclusion of subjects who lacked capacity the results of analyses of the condition from whish they suffer are altered. We suggest that this approach to the study of delirium is more ethical than the usual system of strict exclusion of people who lack capacity to give consent and for whom assent is not available. (shrink)

The Ontology for Biomedical Investigations (OBI) is an ontology that provides terms with precisely defined meanings to describe all aspects of how investigations in the biological and medical domains are conducted. OBI re-uses ontologies that provide a representation of biomedical knowledge from the Open Biological and Biomedical Ontologies (OBO) project and adds the ability to describe how this knowledge was derived. We here describe the state of OBI and several applications that are using it, such as adding semantic expressivity to (...) existing databases, building data entry forms, and enabling interoperability between knowledge resources. OBI covers all phases of the investigation process, such as planning, execution and reporting. It represents information and material entities that participate in these processes, as well as roles and functions. Prior to OBI, it was not possible to use a single internally consistent resource that could be applied to multiple types of experiments for these applications. OBI has made this possible by creating terms for entities involved in biological and medical investigations and by importing parts of other biomedical ontologies such as GO, Chemical Entities of Biological Interest (ChEBI) and Phenotype Attribute and Trait Ontology (PATO) without altering their meaning. OBI is being used in a wide range of projects covering genomics, multi-omics, immunology, and catalogs of services. OBI has also spawned other ontologies (Information Artifact Ontology) and methods for importing parts of ontologies (Minimum information to reference an external ontology term (MIREOT)). The OBI project is an open cross-disciplinary collaborative effort, encompassing multiple research communities from around the globe. To date, OBI has created 2366 classes and 40 relations along with textual and formal definitions. The OBI Consortium maintains a web resource providing details on the people, policies, and issues being addressed in association with OBI. (shrink)

Self-knowledge is the focus of considerable attention from philosophers: Knowing Our Own Minds gives a much-needed overview of current work on the subject, bringing together new essays by leading figures. Knowledge of one's own sensations, desires, intentions, thoughts, beliefs, and other attitudes is characteristically different from other kinds of knowledge: it has greater immediacy, authority, and salience. The contributors examine philosophical questions raised by the distinctive character of self-knowledge, relating it to knowledge of other minds, to rationality and agency, externalist (...) theories of psychological content, and knowledge of language. Together these original, stimulating, and closely interlinked essays demonstrate the special relevance of self-knowledge to a broad range of issues in epistemology, philosophy of mind, and philosophy of language. (shrink)

Il s'agit du temoin le plus ancien d'un cours portant sur les livres II et III au complet du Traite de l'ame d'Aristote. Le cours, enseigne a la Faculte des Arts d'une Universite difficile a preciser (Paris?), est un exemple paradigmatique de la methode litterale (ce qui a permis de reconstituer la version de la Vetus utilisee par le maitre, que l'on pourra ajouter au dossier de l'Aristoteles Latinus) et un temoin precieux de la premiere reception d'Aristote. Le texte permet (...) de constater le retrait d'Avicenne et l'influence croissante d'Averroes (dont le role est cependant purement instrumental, subordonne a l'intelligence purement philosophique du texte d'Aristote). Aucune des grandes doctrines personnelles du commentateur n'est retenue par le maitre. Dans l'etude doctrinale du texte on met en valeur les points du commentaire (nature et puissances de l'ame, l'intellect et les modes de connaissance), et on offre un tableau des doctrines psychologiques professees par les maitres des arts avant 1250 : John Blund, Pierre d'Espagne et d'autres maitres anonymes (tableau complete par un apparat de sources tres riche). On critique la notion de premier Averroisme, car la notion de l'intellect agent comme puissance de l'ame semble etre une contribution proprement latine a l'exegese du De anima. Finalement, on prouve que saint Thomas a eu connaissance de ce commentaire anonyme et qu'il en depend dans sa propre lecture d'Aristote. Cela met en perspective l'originalite de saint Thomas et souligne la contribution des maitres des arts a l'histoire de l'Aristotelisme medieval. (shrink)

In 2012, a U.S. Institute of Medicine report called for a different approach to health care: “Left unchanged, health care will continue to underperform; cause unnecessary harm; and strain national, state, and family budgets.” The answer, they suggested, would be a “continuously learning” health system. Ethicists and researchers urged the creation of “learning health organizations” that would integrate knowledge from patient‐care data to continuously improve the quality of care. Our experience with an ongoing research study on atrial fibrillation—a trial known (...) as IMPACT‐AFib—gave us some insight into one of the challenges that will have to be dealt with in creating these organizations. Although the proposed educational intervention study placed no restrictions on what providers and health plans could do, the oversight team argued that the ethical principle of beneficence did not allow the researchers to be “bystanders” in relation to a control group receiving suboptimal care. In response, the researchers designed a “workaround” that allowed the project to go forward. We believe the experience suggests that what we call “bystander ethics” will create challenges for the kinds of quality improvement research that LHOs are designed to do. (shrink)

Background: Post-traumatic stress disorder is a prevalent, debilitating, and costly psychiatric disorder. Evidenced-based psychotherapies, including Cognitive Processing Therapy, are effective in treating PTSD, although a fair proportion of individuals show limited benefit from such treatments. CPT requires cognitive demands such as encoding, recalling, and implementing new information, resulting in behavioral change that may improve PTSD symptoms. Individuals with PTSD show worse cognitive functioning than those without PTSD, particularly in acquisition of verbal memory. Therefore, memory dysfunction may limit treatment gains in (...) CPT in some individuals with PTSD. Methods and Analysis: Here, we present a protocol describing the Cognition and PsychoTherapy in PTSD study, a prospective, observational study examining how cognitive functioning affects treatment response in CPT for PTSD. The study aims to recruit 105 outpatient veterans with PTSD between the ages of 18 and 70 years. Prior to beginning 12 sessions of CPT, Veteran participants will have standardized assessments of mood and functioning and complete a comprehensive neurocognitive battery assessing episodic learning, attention and speed of processing, language ability, executive control, and emotional functioning. This study aims to fill gaps in the current literature by: examining the specificity of memory effects on treatment response; exploring how baseline cognitive functioning impacts functional outcomes; and examining potential mechanisms, such as memory for treatment content, that might explain the effects of baseline memory functioning on PTSD symptom trajectory. Discussion: If successful, this research could identify clinically relevant neurocognitive mechanisms that may impact PTSD psychotherapy and guide the development of individualized treatments for PTSD. (shrink)

Recent efforts to argue that nonepistemic values have a legitimate role to play in assessing scientific models, theories, and hypotheses typically either reject the distinction between epistemic and nonepistemic values or incorporate nonepistemic values only as a secondary consideration for resolving epistemic uncertainty. Given that scientific representations can legitimately be evaluated not only based on their fit with the world but also with respect to their fit with the needs of their users, we show in two case studies that nonepistemic (...) values can play a legitimate role as factors that override epistemic considerations in assessing scientific representations for practical purposes. (shrink)

Haec quae est a nobis prolata laudatio obsignata erat creta ilia Asiatica quae fere est omnibus nota nobis, qua utuntur omnes non modo in publicis sed etiam in privatis litteris quas cotidie videmus mitti a publicanis, saepe uni cuique nostrum.

Death from cancer is usually due to metastasis. Fortunately, most cells that escape from a primary tumor fail to form metastases. Identifying reasons for this failure will help development of anti‐metastatic therapies. Intravital videomicroscopy (IVVM) can be used to observe cancer cells injected into live animals. Co‐injected microspheres can be used to assess cell survival. These techniques have been used to show that circulating tumor cells generally arrest in the microcirculation and may extravasate with high efficiency. While many tumor cells (...) may survive in a secondary site, only a small subset form micrometastases and only a subset of these micrometastases persist to form vascularized macrometastases. Furthermore, solitary tumor cells may remain dormant for long periods of time in secondary sites. These findings suggest that metastatic growth and angiogenesis are prime targets for anti‐metastatic therapy. BioEssays 24:885–893, 2002. © 2002 Wiley Periodicals, Inc. (shrink)